A Novel Ring Closure to Furo [ 2 , 3 - b ] quinoxaline [ 1 , 2 ]
نویسنده
چکیده
3-(l-Halo-2-oxo-2-substitutedethyl)-2(lH)quinoxalinones, Furo[2,3-b]quinoxalines An efficient method for the synthesis of furo[2,3-b]quinoxalines has been devised. Thus, 3-halo-2-arylfuro[2,3-b]quinoxalines, 5a-5c were synthesized by the action of conc. H2SO4 on 3-(l-halo-2-oxo-2-arylethyl)-2(lH)quinoxalinones, 3b, 3c and 3f respectively. When 3-(1 -halo-2-oxo-2-substitutedethyl)-2(1H)quinoxalinones 3d and 3e (substituent = «-butyl, ethoxy) were utilized in this reaction 3-halomethylene-2(lH)quinoxalinone 6 a and 6b were obtained in high yield.
منابع مشابه
One-pot three-component synthesis of quinoxaline and phenazine ring systems using Fischer carbene complexes
One-pot three-component coupling of o-alkynylheteroaryl carbonyl derivatives with Fischer carbene complexes and dienophiles leading to the synthesis of quinoxaline and phenazine ring systems has been investigated. This involves the generation of furo[3,4-b]pyrazine and furo[3,4-b]quinoxaline as transient intermediates, which were trapped with Diels-Alder dienophiles. This is the first report on...
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